Reactive Oxygen Species in Biology and Human Health
Shamim I. Ahmad的生物学和人类健康中的活性氧物质
英文| 2016 | ISBN:1498735452 | 567页| PDF | 45,5 MB
与其他狭隘的书籍不同,活性氧物种在生物学和人类健康方面提供了全面的ROS概述。它涵盖了当前的研究现状,并提供了未来研究目标的指标。另外,它有权回顾了活性氧对各种人类疾病的影响,并讨论了抵抗氧化应激的抗氧化剂和其他化合物。
由七部分组成,第一部分介绍了ROS的引入,检测和生产,强调酚类化合物和维生素E作为抗氧化剂的能力。本节还突出了脂蛋白相关氧化应激的作用。第二部分讨论了脑中铁积累的重要性,导致一组神经变性疾病(ND)的发展,并鉴定了与帕金森综合征相关疾病相关的脑铁积聚(NBIA)的神经变性的几个致病基因。
第三部分讨论了一些ND,包括肌萎缩性侧索硬化(ALS),阿尔茨海默病(AD),亨廷顿病(HD),癫痫和多发性硬化(MS)。第四部分讨论由ROS引起的自身免疫性疾病,包括哮喘,自身免疫性肝病,类风湿性关节炎,甲状腺疾病,原发性胆汁性肝硬化和系统性红斑狼疮。第五部分分析了许多不同的癌症,包括肺癌,乳腺癌和黑素瘤,以及可能的治疗方案。
第六部分讨论由ROS引起的心血管疾病(CVD),呈现引起炎症的ROS相关复合生物化学过程是CVD的重要原因,并解释了类胡萝卜素在预防CVD中的作用。最后一部分涉及氧化应激引起的其他人类疾病,包括镰状细胞病,非酒精性脂肪性肝炎,视网膜病变,纤维肌痛,慢性阻塞性肺病,哮喘,肺动脉高压,不孕和人类皮肤衰老。
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Reactive Oxygen Species in Biology and Human Health by Shamim I. Ahmad
English | 2016 | ISBN: 1498735452 | 567 pages | PDF | 45,5 MB
Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress.
Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders.
The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens.
Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.
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